Estrogen-like compounds for ischemic neuroprotection.
نویسندگان
چکیده
We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-alpha or estrogen receptor-beta, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.
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ورودعنوان ژورنال:
- Stroke
دوره 35 11 Suppl 1 شماره
صفحات -
تاریخ انتشار 2004